Irina came to biology from an engineering background (B.S.E. in Chemical Engineering, Princeton University) and values the importance of a multidisciplinary approach to solve biomedical problems. She completed her Ph.D. training in Genomics & Computational Biology with Klaus Kaestner at University of Pennsylvania, where she studied transcriptional regulation in liver metabolism. For her postdoctoral fellowship, she trained with Aviv Regev at the Broad Institute, applying computational analysis of high-throughput data to epigenetic mechanisms in aging liver. Irina is both an experimental and computational biologist with extensive expertise in liver metabolism, transcriptional and chromatin regulation, and computational analysis of next-generation sequencing data.
Wei X, Murphy MA, Reddy NA, Hao Y, Eggertsen TG, Saucerman JJ, Bochkis IM.Redistribution of lamina-associated domains reshapes binding of pioneer factor FOXA2 in development of nonalcoholic fatty liver disease. Genome Research. 2022 Dec 15. doi: 10.1101/gr.277149.122. PMID: 36522168
Kain J, Wei X, Reddy NA, Price AJ, Woods C, Bochkis IM. Pioneer factor Foxa2 enables ligand-dependent activation of type II nuclear receptors FXR and LXRα. Molecular Metabolism. 2021. Nov;53:101291.
doi: 10.1016/j.molmet.2021.101291. Epub 2021 Jul 8. PMID: 34246806 PMCID: PMC8350412
Price AJ, Manjegowda MC, Kain J, Anandh S, Bochkis IM. Hdac3, Setdb1, and Kap1 mark H3K9me3/H3K14ac bivalent regions in young and aged liver. Aging Cell. 2020;19(2):e13092. doi:10.1111/acel.13092
Full list of publication can be found here: https://pubmed.ncbi.nlm.nih.gov/?term=Bochkis&sort=date